Research Article

Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma

Table 2

Target-gene pairs of active ingredients of PRA.

Target geneGene name

26S proteasome non-ATPase regulatory subunit 3PSMD3
5-Hydroxytryptamine 2A receptorHTR2A HTR2
5-Hydroxytryptamine receptor 3AHTR3A
AcetylcholinesteraseACHE
Activator of 90 kDa heat shock protein ATPase homolog 1AHSA1
Aldo-keto reductase family 1 member C3AKR1C3
Alpha-1D adrenergic receptorADRA1B
Androgen receptorAR
AntileukoproteinaseSLPI
Apoptosis regulator BAXBAX
Apoptosis regulator Bcl-2BCL2
Arachidonate 5-lipoxygenaseALOX5
Aryl hydrocarbon receptorAHR
Beta-2 adrenergic receptorADRB2 ADRB2R, B2AR
Beta-lactamaseblaC
CalmodulinCAMKK2
Caspase-3CASP3
Caspase-8CASP8
Caspase-9CASP9 MCH6
CatalaseCAT
Cell division control protein 2 homologCDC42
CGMP-inhibited 3,5-cyclic phosphodiesterase APDE3A
Coagulation factor VIIF7
Coagulation factor XaF10
Cytochrome P450 1A1CYP1A1
Cytochrome P450 1A2CYP1A2
Cytochrome P450 1B1CYP1B1
Cytochrome P450 3A4CYP3A4
Cytochrome P450-camcamC
Dipeptidyl peptidase IVDPP4
DNA topoisomerase IITOP2
Dopamine D1 receptorDRD5 DRD1B, DRD1L2
E-SelectinSELE
Estrogen receptorESR1
Gamma-aminobutyric acid receptor subunit alpha-1GABRA1
Gamma-aminobutyric-acid receptor alpha-2 subunitGABRA2
Gamma-aminobutyric-acid receptor alpha-3 subunitGABRA3
Gamma-aminobutyric-acid receptor alpha-5 subunitGABRA5
Glutathione S-transferase Mu 1GSTM1
Glutathione S-transferase Mu 2GSTM2
Glutathione S-transferase PGSTP1
Heat shock protein HSP 90HSP90AA1 HSP90A, HSPC1, HSPCA
Heme oxygenase 1HMOX1 HO, HO1
Hyaluronan synthase 2HAS2
Inhibitor of nuclear factor kappa-B kinase subunit betaIKBKB
Insulin receptorINSR
Intercellular adhesion molecule 1ICAM1
Interleukin-6IL6
Interstitial collagenaseMMP1
Lipopolysaccharide-binding proteinLBP
Microtubule-associated protein 2Map2
Mineralocorticoid receptorNR3C2
Mitogen-activated protein kinase 8MAPK8
Monocyte differentiation antigen CD14CD14
mRNA of PKA catalytic subunit C-alphaPRKACA
Muscarinic acetylcholine receptor M1CHRM1
Muscarinic acetylcholine receptor M2CHRM2
Muscarinic acetylcholine receptor M3CHRM3
Muscarinic acetylcholine receptor M4CHRM4
Mu-type opioid receptorOPRM1 MOR1
NAD(P)H dehydrogenase [quinone] 1NQO1 DIA4, NMOR1
Neuronal acetylcholine receptor protein, alpha-7 chainCHRNA7 NACHRA7
Neuronal acetylcholine receptor subunit alpha-2CHRNA2
Nitric-oxide synthase, inducibleNOS2
Nitric-oxide synthase, endothelialNOS3
Nuclear receptor coactivator 2NCOA2
Nuclear receptor subfamily 1 group I member 2NR1I2
Pancreatic alpha-amylaseAMY2A
Peroxidase C1APRXC1A
Peroxisome proliferator activated receptor gammaPPARG
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoformPIK3CG
Potassium voltage-gated channel subfamily H member 2KCNH2 ERG, ERG1, HERG
Progesterone receptorPGR
Prostaglandin G/H synthase 1PTGS1
Prostaglandin G/H synthase 2PTGS2
Protein kinase C-alpha typePRKCA
RAC-alpha serine/threonine-protein kinaseAKT1
Retinoic acid receptor RXR-alphaRXRA
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformPPP3CA
Serum paraoxonase/arylesterase 1PON1
Signal transducer and activator of transcription 1-alpha/betaSTAT1
Sodium channel protein type 5 subunit alphaSCN5A
Sodium-dependent noradrenaline transporterSLC6A2
Solute carrier family 2, facilitated glucose transporter member 4SLC2A4
ThrombinF2
Transcription factor AP-1JUN
Transcription factor p65RELA
Transforming growth factor beta-1TGFB1
Trypsin-1PRSS1
Tumor necrosis factorTNF