Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases

Figure 1

Theoretical effects of USAG-1 in renal diseases. The secretion of USAG-1 in the distal tubule increases when the kidney is damaged by ischemia reperfusion, drug toxicity, sepsis, or other factors. It aggravates tubule damage, inflammatory cell infiltration, and interstitial fibrosis by affecting the activity of the BMP7/TGF-β and Wnt/β-catenin signaling pathways.