miR-100 Suppresses the Proliferation, Invasion, and Migration of Hepatocellular Carcinoma Cells via Targeting CXCR7

Figure 5

CXCR7 partially reverses the effects of overexpressing miR-100 on LM3 cells. (a, b) Relative CXCR7 protein expression in LM3 cells after transfection of miR-100 or cotransfection of miR-100 and CXCR7. (c) CCK-8 results showed that CXCR7 overexpression partially reversed the inhibitive effects of miR-100 on LM3 cell proliferation. (d, e) miR-100 upregulation arrested the G0/G1 to S phase transition in LM3 cells, while CXCR7 exerted reverse effects. (f, g) Transwell assay showed that CXCR7 overexpression partially reversed the inhibitive effects of miR-100 on LM3 cell invasion. (h, i) miR-100 upregulation reduced the protein levels of VEGF and MMP2, while CXCR7 increased their expression. .

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