Epitope-Based Immunoinformatic Approach on Heat Shock 70 kDa Protein Complex of Cryptococcus neoformans var. grubii

Table 3

List of promising epitopes of heat shock 70 kDa protein that had the highest binding affinity with MHC-I alleles in terms of IC₅₀ and percentile rank.

Epitopes	Start	End	Allele	IC50	Percentile
YVYDTRGKL	579	587	HLA-A02:06	274.73	1.8
	579	587	HLA-A68:02	359.64	1.5
	579	587	HLA-B07:02	488.64	1.3
	579	587	HLA-C03:03	10.15	0.06
	579	587	HLA-C06:02	350.13	0.13
	579	587	HLA-C07:01	133.84	0.04
	579	587	HLA-C12:03	10.95	0.03
	579	587	HLA-C14:02	10.45	0.02
	579	587	HLA-C15:02	475.11	0.24
FTQLVAAYL	115	123	HLA-A02:01	387.43	2.6
	115	123	HLA-A02:06	166.27	1.4
	115	123	HLA-A68:02	21.89	0.22
	115	123	HLA-C03:03	335.75	0.6
	115	123	HLA-C05:01	356.66	0.18
	115	123	HLA-C14:02	74.62	0.14
	115	123	HLA-C15:02	276.33	0.16
FYRQGAFEL	437	445	HLA-A23:01	163.92	0.47
	437	445	HLA-A24:02	379.48	0.6
	437	445	HLA-C03:03	234.95	0.5
	437	445	HLA-C07:02	27.33	0.02
	437	445	HLA-C12:03	429.65	0.5
	437	445	HLA-C14:02	10.8	0.02

Top promising epitopes with strong binding affinity and massive global population coverage.