Toll-Like Receptor Homolog CD180 Expression Is Diminished on Natural Autoantibody-Producing B Cells of Patients with Autoimmune CNS Disorders

Figure 2

Analysis of CD180 expression in B cell subsets of neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) patients. (a) Flow cytometric analysis of CD180 expression in naïve (CD19⁺CD27^-) and memory (CD19⁺CD27⁺) B cells in peripheral blood of NMOSD (), MS (), and healthy controls (HC) (). (b) CD180 mRNA expression in B cells of NMOSD () and MS () patients compared to HC (). Gene expression was normalized to HC, and the horizontal line (value 1) represents the expression of control samples. Changes in gene expression are shown as relative quantification (RQ) values. (c) Flow cytometric analysis of CD180 expression in CD19⁺CD27^-IgD⁺ naïve, CD19⁺CD27^-IgD^- double-negative (DN), CD19⁺CD27⁺IgD^- switched (S) memory, and CD19⁺CD27⁺IgD⁺ nonswitched (NS) memory B cells in peripheral blood of NMOSD (), MS (), and healthy controls (HC) (). Data are shown as ; .

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