TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer

Figure 4

The PY-NLS motif is responsible for the nuclear import of FUBP1. (a) The cylinder shows the domain of the PY-NLS motif and function of FUBP1. Alignment revealing the FUBP1 PY-NLS motif from various mammalian species. (b) Immunoblots shows the FUBP1 and mutant levels in the nucleoplasm and cytoplasm of HEK-293 cell. (c) Immunoblots shows the PY-NLS and mutant levels in the nucleoplasm and cytoplasm. (d) Confocal microscopy of FUBP1 and mutant levels. (e) Confocal microscopy of PY-NLS and mutant levels. Scar bar 20 μm.

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