TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer

<div>Karyopherin TNPO1 mediates nuclear import of FUBP1. (a) Immunoblots of the TNPO1 levels following immunoprecipitation of FUBP1 in MS751 and Siha cells. (b) Immunoblots of the FUBP1 levels following immunoprecipitation of TNPO1. (c, d) Immunoblots shows the FUBP1 levels in the nucleoplasm and cytoplasm after transfecting with siTNPO1 or M9M. (e, f) Confocal microscopy shows the FUBP1 protein after transfecting with siTNPO1 or M9M. (g, h) The mRNA level of <i>NRP1</i> and <i>MYC</i> after FUBP1 or TNPO1 knockdown. (i) The mRNA level of <i>NRP1</i> and <i>MYC</i> after M9M expression. 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Scar bar: 20 <i>μ</i>m. 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Journal of Immunology Research

fig5

Figure 5

Figure 5: TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer 