Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis

Figure 2

Interaction of different cytokines between cells in CRSwNP. In CRSwNP, Tregs secrete TGF-β to promote Th17 differentiation. Th17 inhibits Treg through IL-17 and IL-21, resulting in an imbalance between Treg and Th17 cells. APCs (such as DCs) activate Th17 cells via IL-6. SEB, secreted by Staphylococcus aureus, downregulates the number of Tregs. Meanwhile, Tregs produce IL-10 to inhibit the function of DCs and activate eosinophil/neutrophils by IL-2, and Treg cells also proliferate by autocrine IL-2 and TGF-β.