Intranasal Vaccination with rePcrV Protects against Pseudomonas aeruginosa and Generates Lung Tissue-Resident Memory T Cells

Figure 4

CD4⁺ T_RM cells protect against Pseudomonas aeruginosa pulmonary infection. (a) The survival of naïve C57BL/6 mice with or without FTY720 treatment and rePcrV-immunized mice with or without FTY720 treatment (). by log-rank test. (b) Global disease score in 4 groups of mice after challenge with of P. aeruginosa XN-1 (). (c) Weight loss in the naïve mice with or without FTY720 treatment and rePcrV-immunized mice with or without FTY720 treatment after challenge with of P. aeruginosa XN-1 (). (d) Lung CFU 24 hours after infection in the naïve mice with or without FTY720 treatment and rePcrV-immunized mice with or without FTY720 treatment (). (e) Representative H and E stains in naïve mice with or without FTY720 treatment and rePcrV-immunized mice with or without FTY720 treatment lung 24 hours post-P. aeruginosa XN-1 challenge are shown () (). Significant differences are designated by using Student’s -test. ; ; ; .

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