Knocking Out of CEACAM1 Can Reduce Oxidative Stress and Promote Cell Proliferation in the HPMVECs under Hypoxia

Figure 1

Culture of HPMVECs under OGD/R results in loss of cell viability and increased expression of CEACAM1 and TNFa. (a) Increased time under hypoxic conditions resulted in decreased cell viability in wild type HPMVECs. Assays were performed as biological replicates of three. The 8 h OGD-treated group exhibited significantly lower viability than 4 h OGD-treated group (). (b) Extended hypoxia yields smaller and more spherical cells and lower cell numbers compared to controls. (c) Increased time under hypoxic conditions leads to increased expression CEACAM1 and TNF-α protein.

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