Differences of Circulating CD25^hi Bregs and Their Correlations with CD4 Effector and Regulatory T Cells in Autoantibody-Positive T1D Compared with Age-Matched Healthy Individuals

Figure 2

The effect of disease status and T1D risk loci (rs12251307 and rs2104286) in IL2RA on CD25 expression in CD19⁺ B cells. Correlation between the frequency of CD25^hi Bregs in CD19⁺ B cells and age at (a) T1D diagnosis and (b) T1D duration in T1D subjects. The correlation was determined by the Spearman rank test. (c, d) Con represents healthy controls. For both healthy controls and T1D individuals, comparisons between wild genotype and homozygote+ heterozygote and were performed by unpaired -test with Welch’s correction. A total of 40 T1D individuals and 40 healthy controls were enrolled for the analysis. A value below 0.05 indicates a significant difference for different genotypes in each group.

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