Differences of Circulating CD25<sup>hi</sup> Bregs and Their Correlations with CD4 Effector and Regulatory T Cells in Autoantibody-Positive T1D Compared with Age-Matched Healthy Individuals

<div>Differences in circulating naïve/CM/EM subsets in total CD4 effector T cells between autoantibody-positive T1D and age-matched healthy individuals. (a) Representative dot plots for gating naïve/CM/EM subsets in total CD4 effector T cells in a healthy donor (HD) and T1D subject. (b) Evaluation of circulating naïve/CM/EM subsets in total CD4 effector T cells between T1D and healthy individual controls. A <svg height="8.68572pt" id="M26" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g></svg> value below 0.05 indicates a significant difference between groups.</div>

Journal of Immunology Research

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Figure 4

Figure 4: Differences of Circulating CD25<sup>hi</sup> Bregs and Their Correlations with CD4 Effector and Regulatory T Cells in Autoantibody-Positive T1D Compared with Age-Matched Healthy Individuals 

Figure 4 | Differences of Circulating CD25hi Bregs and Their Correlations with CD4 Effector and Regulatory T Cells in Autoantibody-Positive T1D Compared with Age-Matched Healthy Individuals 