Differences of Circulating CD25^hi Bregs and Their Correlations with CD4 Effector and Regulatory T Cells in Autoantibody-Positive T1D Compared with Age-Matched Healthy Individuals

Figure 5

Correlations between CD25^hi Bregs and effector CD4 T cells, CD4 Tregs, and CTLA-4⁺ Tregs in healthy control and T1D individuals. Correlation analysis between CD25^hi Bregs and effector CD4 T cells from (a) healthy donors (HD) and (b) T1D individuals. Correlation analysis between CD25^hi Bregs and CD4 Tregs from (c) HD and (d) T1D individuals. Correlation analysis between CD25^hi Bregs and CTLA-4⁺ Tregs from (e) HD and (f) T1D individuals. Spearman correlations were performed for these correlations. A value < 0.05 was considered significant.

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