Mechanism of Neonatal Intestinal Injury Induced by Hyperoxia Therapy

Figure 1

Injury of physical and immune barriers to hyperoxia therapy in neonates. During hyperoxia exposure, the number of goblet cells in the intestine decreased and the mucous layer damaged [10]. Moreover, it inhibits the expression of TJ between cells and increases intestinal permeability [10–12]. In the immune barrier, high oxygen increased SIgA content in the mucus layer by stimulating the SC expression [16, 25]. In addition, high oxygen also increases IL-17D, IL-10, and IFN-γ, resulting in a disturbance of cytokine levels [12, 32].