Effects of Hyperthyroidism on Venous Thromboembolism: A Mendelian Randomization Study

Table 5

Univariate Mendelian randomization analysis for the effects of hypothyroidism on venous thromboembolism risk.

SNP	EAE	OAE	EAO	OAO	Chr	Exposure			Outcome
						Effect	SE	value	Effect	SE	value
rs10036386	T	C	T	C	5	0.0032	0.0005	1.75E-09	-0.0022	0.016	0.8916
rs1032129	C	A	C	A	8	-0.0030	0.0005	2.67E-08	-0.0134	0.0161	0.4059
rs10424978	A	C	A	C	19	-0.0042	0.0005	7.21E-15	0	0.0162	0.998
rs1088898	T	G	T	G	17	0.0034	0.0006	4.22E-08	-0.0182	0.0173	0.2936
rs10956412	C	A	C	A	8	-0.0051	0.0007	5.84E-13	-0.0011	0.027	0.9661
rs11052877	G	A	G	A	12	-0.0058	0.0005	9.31E-27	-0.0127	0.0161	0.4304
rs111618453	A	G	A	G	13	0.0058	0.0006	4.33E-23	0.0019	0.0174	0.9144
rs11258303	A	C	A	C	10	0.0037	0.0006	5.59E-10	-0.0083	0.0167	0.6174
rs113229608	A	C	A	C	3	0.0065	0.0011	1.17E-09	-0.0584	0.0415	0.1588
rs11571297	C	T	C	T	2	-0.0086	0.0005	5.34E-61	-0.0176	0.0164	0.2833
rs11675342	T	C	T	C	2	0.0046	0.0005	1.67E-18	0.002	0.016	0.9001
rs11706511	G	A	G	A	3	0.0047	0.0008	2.47E-09	0.0356	0.0227	0.1166
rs11783023	T	C	T	C	8	-0.0033	0.0006	1.06E-08	0.0017	0.0164	0.9189
rs12117927	A	C	A	C	1	0.0033	0.0005	8.18E-10	-0.0295	0.0165	0.0749
rs12582330	T	G	T	G	12	-0.0042	0.0006	1.10E-12	-0.0128	0.017	0.452
rs12980063	G	A	G	A	19	-0.0034	0.0005	1.74E-10	-0.0138	0.0166	0.405
rs13090803	T	G	T	G	3	0.0051	0.0006	2.09E-15	0.0397	0.0229	0.0826
rs13145888	C	T	C	T	4	-0.0060	0.0006	2.45E-21	0.0351	0.0242	0.1465
rs13333582	C	T	C	T	16	0.0072	0.0013	1.80E-08	-0.0181	0.0413	0.6610
rs13399762	G	A	G	A	2	0.0067	0.0011	4.25E-09	0.0136	0.042	0.7470
rs142997491	G	A	G	A	16	0.0150	0.0024	2.81E-10	0.0296	0.0538	0.5826
rs1534430	T	C	T	C	2	-0.0040	0.0005	3.99E-14	-0.0029	0.0161	0.857
rs1549142	T	C	T	C	19	0.0041	0.0006	3.90E-11	0.0124	0.0186	0.5039
rs16903097	G	T	G	T	8	-0.0045	0.0008	3.97E-09	-0.0154	0.0248	0.5346
rs17020110	C	T	C	T	1	0.0041	0.0006	2.07E-12	-0.002	0.0189	0.9161
rs1790604	G	A	G	A	18	-0.0032	0.0005	5.49E-10	-0.0402	0.0159	0.01171
rs2111485	G	A	G	A	2	0.0038	0.0005	7.84E-13	0.0023	0.0161	0.8845
rs2123340	A	G	A	G	9	-0.0037	0.0005	7.76E-12	-0.0084	0.0167	0.6136
rs221786	C	T	C	T	7	0.0050	0.0008	1.53E-09	-0.0246	0.0222	0.2678
rs229540	G	T	G	T	22	0.0050	0.0005	8.83E-22	0.0251	0.0161	0.1204
rs2412974	T	C	T	C	22	-0.0031	0.0005	8.01E-09	0.0036	0.0162	0.8243
rs244672	T	C	T	C	5	-0.0046	0.0008	4.84E-09	-0.0153	0.0185	0.4085
rs2523483	G	T	G	T	6	-0.0066	0.0009	4.37E-13	-0.0254	0.0746	0.7332
rs2736191	G	C	G	C	6	-0.0094	0.0017	1.59E-08	-0.0548	0.0354	0.1212
rs2745803	G	A	G	A	20	-0.0037	0.0006	9.31E-09	0.021	0.0223	0.3448
rs28157	T	G	T	G	5	-0.0035	0.0006	4.16E-10	-0.0339	0.0171	0.04697
rs2823272	A	T	A	T	21	-0.0036	0.0006	2.03E-10	-0.0044	0.0183	0.8109
rs3184504	C	T	C	T	12	-0.0099	0.0005	1.10E-81	-0.044	0.0161	0.0062
rs3775291	T	C	T	C	4	-0.0040	0.0006	1.05E-12	0.0184	0.0171	0.2813
rs3850765	C	T	C	T	10	0.0031	0.0005	2.76E-09	0.0196	0.0174	0.2613
rs4081335	C	T	C	T	1	-0.0064	0.0012	3.55E-08	-4E-04	0.032	0.9889
rs4263621	A	G	A	G	6	0.0030	0.0005	1.48E-08	0.0036	0.0159	0.8189
rs4276275	T	C	T	C	4	0.0034	0.0005	5.84E-11	0.0039	0.0159	0.8079
rs4409785	C	T	C	T	11	0.0065	0.0007	4.31E-21	0.0102	0.0212	0.6326
rs4444866	T	C	T	C	4	-0.0032	0.0006	2.85E-08	0.0146	0.0175	0.4058
rs60600003	G	T	G	T	7	0.0050	0.0009	7.19E-09	-0.0184	0.0263	0.485
rs61759532	T	C	T	C	17	0.0042	0.0006	1.26E-11	-0.0068	0.0203	0.7381
rs62076510	G	T	G	T	17	0.0052	0.0007	3.46E-13	0.0343	0.021	0.1031
rs6426808	A	G	A	G	1	0.0033	0.0005	3.13E-10	-0.0108	0.0159	0.4976
rs654537	A	G	A	G	6	0.0060	0.0005	2.13E-29	-0.0029	0.0159	0.856
rs6584277	G	A	G	A	10	-0.0032	0.0005	8.79E-10	0.0229	0.0159	0.1488
rs66749983	T	A	T	A	13	0.0036	0.0006	1.39E-10	-0.0189	0.0167	0.2585
rs6679677	A	C	A	C	1	0.0201	0.0009	1.07E-122	-0.03	0.0224	0.1796
rs6833591	G	A	G	A	4	-0.0032	0.0005	6.10E-09	-0.0175	0.0193	0.3621
rs683763	T	G	T	G	10	0.0031	0.0006	2.57E-08	-0.0128	0.0162	0.4288
rs6992869	C	T	C	T	8	0.0030	0.0005	2.56E-08	0.0017	0.016	0.915
rs705702	G	A	G	A	12	0.0037	0.0005	1.96E-11	0.001	0.0172	0.9558
rs7090530	A	C	A	C	10	0.0042	0.0005	2.94E-15	-0.0055	0.0169	0.7451
rs71508903	T	C	T	C	10	0.0063	0.0007	3.21E-21	0.0202	0.0205	0.3242
rs736374	A	G	A	G	11	0.0041	0.0005	2.48E-14	0.005	0.0166	0.7631
rs7441808	G	A	G	A	4	0.0035	0.0006	3.53E-10	-1E-04	0.0176	0.9964
rs7582694	G	C	G	C	2	-0.0070	0.0006	2.61E-29	0.0086	0.0188	0.6460
rs761357	T	A	T	A	6	0.0033	0.0005	6.81E-10	0.0137	0.0167	0.4118
rs76428106	C	T	C	T	13	0.0271	0.0024	4.26E-30	-0.1052	0.0736	0.1528
rs7649344	C	T	C	T	3	-0.0030	0.0005	1.23E-08	0.003	0.0164	0.8565
rs76518703	G	A	G	A	6	-0.0101	0.0012	1.42E-16	-0.061	0.042	0.1464
rs7768019	G	C	G	C	6	-0.0081	0.0006	1.31E-41	0.0065	0.0178	0.7173
rs7905731	C	T	C	T	10	-0.0031	0.0005	2.66E-09	0.0207	0.0165	0.2095
rs8008961	T	C	T	C	14	-0.0034	0.0006	5.54E-09	0.0027	0.0173	0.8763
rs8043085	T	G	T	G	15	0.0043	0.0006	4.47E-12	-0.0021	0.0189	0.9122
rs8054578	G	A	G	A	16	-0.0036	0.0006	8.95E-09	0.0043	0.0209	0.8381
rs853303	G	A	G	A	8	-0.0037	0.0005	2.30E-12	-0.0191	0.0171	0.2658
rs911760	A	C	A	C	9	0.0042	0.0007	5.10E-10	0.0129	0.0195	0.5062
rs925489	T	C	T	C	9	0.0099	0.0006	1.52E-71	-0.0248	0.0166	0.1358
rs926103	C	T	C	T	1	-0.0030	0.0005	4.92E-08	-0.0657	0.0164	5.91E-05
rs9277569	T	C	T	C	6	0.0084	0.0008	1.36E-23	0	0.0226	0.9997
rs933243	A	C	A	C	6	-0.0056	0.0006	3.90E-24	-0.0104	0.0165	0.5268
rs9497965	T	C	T	C	6	0.0036	0.0005	5.19E-12	-0.0217	0.0168	0.1971
rs9815073	A	C	A	C	3	-0.0071	0.0006	1.94E-35	-0.004	0.0171	0.813

Abbreviations: SNP: single nucleotide polymorphism; EAE: effect allele exposure; OAE: other allele exposure; EAO: effect allele outcome; OAO: other allele outcome; Chr: chromosome; SE: standard error.