Research Article
Effects of Hyperthyroidism on Venous Thromboembolism: A Mendelian Randomization Study
Table 5
Univariate Mendelian randomization analysis for the effects of hypothyroidism on venous thromboembolism risk.
| SNP | EAE | OAE | EAO | OAO | Chr | Exposure | Outcome | Effect | SE | value | Effect | SE | value |
| rs10036386 | T | C | T | C | 5 | 0.0032 | 0.0005 | 1.75E-09 | -0.0022 | 0.016 | 0.8916 | rs1032129 | C | A | C | A | 8 | -0.0030 | 0.0005 | 2.67E-08 | -0.0134 | 0.0161 | 0.4059 | rs10424978 | A | C | A | C | 19 | -0.0042 | 0.0005 | 7.21E-15 | 0 | 0.0162 | 0.998 | rs1088898 | T | G | T | G | 17 | 0.0034 | 0.0006 | 4.22E-08 | -0.0182 | 0.0173 | 0.2936 | rs10956412 | C | A | C | A | 8 | -0.0051 | 0.0007 | 5.84E-13 | -0.0011 | 0.027 | 0.9661 | rs11052877 | G | A | G | A | 12 | -0.0058 | 0.0005 | 9.31E-27 | -0.0127 | 0.0161 | 0.4304 | rs111618453 | A | G | A | G | 13 | 0.0058 | 0.0006 | 4.33E-23 | 0.0019 | 0.0174 | 0.9144 | rs11258303 | A | C | A | C | 10 | 0.0037 | 0.0006 | 5.59E-10 | -0.0083 | 0.0167 | 0.6174 | rs113229608 | A | C | A | C | 3 | 0.0065 | 0.0011 | 1.17E-09 | -0.0584 | 0.0415 | 0.1588 | rs11571297 | C | T | C | T | 2 | -0.0086 | 0.0005 | 5.34E-61 | -0.0176 | 0.0164 | 0.2833 | rs11675342 | T | C | T | C | 2 | 0.0046 | 0.0005 | 1.67E-18 | 0.002 | 0.016 | 0.9001 | rs11706511 | G | A | G | A | 3 | 0.0047 | 0.0008 | 2.47E-09 | 0.0356 | 0.0227 | 0.1166 | rs11783023 | T | C | T | C | 8 | -0.0033 | 0.0006 | 1.06E-08 | 0.0017 | 0.0164 | 0.9189 | rs12117927 | A | C | A | C | 1 | 0.0033 | 0.0005 | 8.18E-10 | -0.0295 | 0.0165 | 0.0749 | rs12582330 | T | G | T | G | 12 | -0.0042 | 0.0006 | 1.10E-12 | -0.0128 | 0.017 | 0.452 | rs12980063 | G | A | G | A | 19 | -0.0034 | 0.0005 | 1.74E-10 | -0.0138 | 0.0166 | 0.405 | rs13090803 | T | G | T | G | 3 | 0.0051 | 0.0006 | 2.09E-15 | 0.0397 | 0.0229 | 0.0826 | rs13145888 | C | T | C | T | 4 | -0.0060 | 0.0006 | 2.45E-21 | 0.0351 | 0.0242 | 0.1465 | rs13333582 | C | T | C | T | 16 | 0.0072 | 0.0013 | 1.80E-08 | -0.0181 | 0.0413 | 0.6610 | rs13399762 | G | A | G | A | 2 | 0.0067 | 0.0011 | 4.25E-09 | 0.0136 | 0.042 | 0.7470 | rs142997491 | G | A | G | A | 16 | 0.0150 | 0.0024 | 2.81E-10 | 0.0296 | 0.0538 | 0.5826 | rs1534430 | T | C | T | C | 2 | -0.0040 | 0.0005 | 3.99E-14 | -0.0029 | 0.0161 | 0.857 | rs1549142 | T | C | T | C | 19 | 0.0041 | 0.0006 | 3.90E-11 | 0.0124 | 0.0186 | 0.5039 | rs16903097 | G | T | G | T | 8 | -0.0045 | 0.0008 | 3.97E-09 | -0.0154 | 0.0248 | 0.5346 | rs17020110 | C | T | C | T | 1 | 0.0041 | 0.0006 | 2.07E-12 | -0.002 | 0.0189 | 0.9161 | rs1790604 | G | A | G | A | 18 | -0.0032 | 0.0005 | 5.49E-10 | -0.0402 | 0.0159 | 0.01171 | rs2111485 | G | A | G | A | 2 | 0.0038 | 0.0005 | 7.84E-13 | 0.0023 | 0.0161 | 0.8845 | rs2123340 | A | G | A | G | 9 | -0.0037 | 0.0005 | 7.76E-12 | -0.0084 | 0.0167 | 0.6136 | rs221786 | C | T | C | T | 7 | 0.0050 | 0.0008 | 1.53E-09 | -0.0246 | 0.0222 | 0.2678 | rs229540 | G | T | G | T | 22 | 0.0050 | 0.0005 | 8.83E-22 | 0.0251 | 0.0161 | 0.1204 | rs2412974 | T | C | T | C | 22 | -0.0031 | 0.0005 | 8.01E-09 | 0.0036 | 0.0162 | 0.8243 | rs244672 | T | C | T | C | 5 | -0.0046 | 0.0008 | 4.84E-09 | -0.0153 | 0.0185 | 0.4085 | rs2523483 | G | T | G | T | 6 | -0.0066 | 0.0009 | 4.37E-13 | -0.0254 | 0.0746 | 0.7332 | rs2736191 | G | C | G | C | 6 | -0.0094 | 0.0017 | 1.59E-08 | -0.0548 | 0.0354 | 0.1212 | rs2745803 | G | A | G | A | 20 | -0.0037 | 0.0006 | 9.31E-09 | 0.021 | 0.0223 | 0.3448 | rs28157 | T | G | T | G | 5 | -0.0035 | 0.0006 | 4.16E-10 | -0.0339 | 0.0171 | 0.04697 | rs2823272 | A | T | A | T | 21 | -0.0036 | 0.0006 | 2.03E-10 | -0.0044 | 0.0183 | 0.8109 | rs3184504 | C | T | C | T | 12 | -0.0099 | 0.0005 | 1.10E-81 | -0.044 | 0.0161 | 0.0062 | rs3775291 | T | C | T | C | 4 | -0.0040 | 0.0006 | 1.05E-12 | 0.0184 | 0.0171 | 0.2813 | rs3850765 | C | T | C | T | 10 | 0.0031 | 0.0005 | 2.76E-09 | 0.0196 | 0.0174 | 0.2613 | rs4081335 | C | T | C | T | 1 | -0.0064 | 0.0012 | 3.55E-08 | -4E-04 | 0.032 | 0.9889 | rs4263621 | A | G | A | G | 6 | 0.0030 | 0.0005 | 1.48E-08 | 0.0036 | 0.0159 | 0.8189 | rs4276275 | T | C | T | C | 4 | 0.0034 | 0.0005 | 5.84E-11 | 0.0039 | 0.0159 | 0.8079 | rs4409785 | C | T | C | T | 11 | 0.0065 | 0.0007 | 4.31E-21 | 0.0102 | 0.0212 | 0.6326 | rs4444866 | T | C | T | C | 4 | -0.0032 | 0.0006 | 2.85E-08 | 0.0146 | 0.0175 | 0.4058 | rs60600003 | G | T | G | T | 7 | 0.0050 | 0.0009 | 7.19E-09 | -0.0184 | 0.0263 | 0.485 | rs61759532 | T | C | T | C | 17 | 0.0042 | 0.0006 | 1.26E-11 | -0.0068 | 0.0203 | 0.7381 | rs62076510 | G | T | G | T | 17 | 0.0052 | 0.0007 | 3.46E-13 | 0.0343 | 0.021 | 0.1031 | rs6426808 | A | G | A | G | 1 | 0.0033 | 0.0005 | 3.13E-10 | -0.0108 | 0.0159 | 0.4976 | rs654537 | A | G | A | G | 6 | 0.0060 | 0.0005 | 2.13E-29 | -0.0029 | 0.0159 | 0.856 | rs6584277 | G | A | G | A | 10 | -0.0032 | 0.0005 | 8.79E-10 | 0.0229 | 0.0159 | 0.1488 | rs66749983 | T | A | T | A | 13 | 0.0036 | 0.0006 | 1.39E-10 | -0.0189 | 0.0167 | 0.2585 | rs6679677 | A | C | A | C | 1 | 0.0201 | 0.0009 | 1.07E-122 | -0.03 | 0.0224 | 0.1796 | rs6833591 | G | A | G | A | 4 | -0.0032 | 0.0005 | 6.10E-09 | -0.0175 | 0.0193 | 0.3621 | rs683763 | T | G | T | G | 10 | 0.0031 | 0.0006 | 2.57E-08 | -0.0128 | 0.0162 | 0.4288 | rs6992869 | C | T | C | T | 8 | 0.0030 | 0.0005 | 2.56E-08 | 0.0017 | 0.016 | 0.915 | rs705702 | G | A | G | A | 12 | 0.0037 | 0.0005 | 1.96E-11 | 0.001 | 0.0172 | 0.9558 | rs7090530 | A | C | A | C | 10 | 0.0042 | 0.0005 | 2.94E-15 | -0.0055 | 0.0169 | 0.7451 | rs71508903 | T | C | T | C | 10 | 0.0063 | 0.0007 | 3.21E-21 | 0.0202 | 0.0205 | 0.3242 | rs736374 | A | G | A | G | 11 | 0.0041 | 0.0005 | 2.48E-14 | 0.005 | 0.0166 | 0.7631 | rs7441808 | G | A | G | A | 4 | 0.0035 | 0.0006 | 3.53E-10 | -1E-04 | 0.0176 | 0.9964 | rs7582694 | G | C | G | C | 2 | -0.0070 | 0.0006 | 2.61E-29 | 0.0086 | 0.0188 | 0.6460 | rs761357 | T | A | T | A | 6 | 0.0033 | 0.0005 | 6.81E-10 | 0.0137 | 0.0167 | 0.4118 | rs76428106 | C | T | C | T | 13 | 0.0271 | 0.0024 | 4.26E-30 | -0.1052 | 0.0736 | 0.1528 | rs7649344 | C | T | C | T | 3 | -0.0030 | 0.0005 | 1.23E-08 | 0.003 | 0.0164 | 0.8565 | rs76518703 | G | A | G | A | 6 | -0.0101 | 0.0012 | 1.42E-16 | -0.061 | 0.042 | 0.1464 | rs7768019 | G | C | G | C | 6 | -0.0081 | 0.0006 | 1.31E-41 | 0.0065 | 0.0178 | 0.7173 | rs7905731 | C | T | C | T | 10 | -0.0031 | 0.0005 | 2.66E-09 | 0.0207 | 0.0165 | 0.2095 | rs8008961 | T | C | T | C | 14 | -0.0034 | 0.0006 | 5.54E-09 | 0.0027 | 0.0173 | 0.8763 | rs8043085 | T | G | T | G | 15 | 0.0043 | 0.0006 | 4.47E-12 | -0.0021 | 0.0189 | 0.9122 | rs8054578 | G | A | G | A | 16 | -0.0036 | 0.0006 | 8.95E-09 | 0.0043 | 0.0209 | 0.8381 | rs853303 | G | A | G | A | 8 | -0.0037 | 0.0005 | 2.30E-12 | -0.0191 | 0.0171 | 0.2658 | rs911760 | A | C | A | C | 9 | 0.0042 | 0.0007 | 5.10E-10 | 0.0129 | 0.0195 | 0.5062 | rs925489 | T | C | T | C | 9 | 0.0099 | 0.0006 | 1.52E-71 | -0.0248 | 0.0166 | 0.1358 | rs926103 | C | T | C | T | 1 | -0.0030 | 0.0005 | 4.92E-08 | -0.0657 | 0.0164 | 5.91E-05 | rs9277569 | T | C | T | C | 6 | 0.0084 | 0.0008 | 1.36E-23 | 0 | 0.0226 | 0.9997 | rs933243 | A | C | A | C | 6 | -0.0056 | 0.0006 | 3.90E-24 | -0.0104 | 0.0165 | 0.5268 | rs9497965 | T | C | T | C | 6 | 0.0036 | 0.0005 | 5.19E-12 | -0.0217 | 0.0168 | 0.1971 | rs9815073 | A | C | A | C | 3 | -0.0071 | 0.0006 | 1.94E-35 | -0.004 | 0.0171 | 0.813 |
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Abbreviations: SNP: single nucleotide polymorphism; EAE: effect allele exposure; OAE: other allele exposure; EAO: effect allele outcome; OAO: other allele outcome; Chr: chromosome; SE: standard error.
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