Effects of Hyperthyroidism on Venous Thromboembolism: A Mendelian Randomization Study

Table 6

Mendelian randomization analysis for estimating the associations between thyroid function and dysfunction and venous thromboembolism risk.

Exposure	Outcome	Ancestry	MR
			Methods	nSNP	Beta	OR (95% CI)	value
FT4	Venous thromboembolism	European	IVW	15	-0.009	0.991 (0.825, 1.190)	0.919
			MR-Egger	15	0.038	1.039 (0.667, 1.619)	0.869
			Weighted median	15	0.024	1.024 (0.858, 1.224)	0.789
			Sample mode	15	-0.024	0.976 (0.716, 1.330)	0.880
			Weighted mode	15	0.071	1.074 (0.886, 1.302)	0.481
TSH	Venous thromboembolism	European	IVW	36	0.019	1.019 (0.931, 1.115)	0.684
			MR-Egger	36	-0.032	0.968 (0.771, 1.216)	0.782
			Weighted median	36	0.011	1.011 (0.880, 1.161)	0.880
			Sample mode	36	-0.014	0.987 (0.792, 1.230)	0.950
			Weighted mode	36	0.009	1.009 (0.867, 1.175)	0.907
Hyperthyroidism	Venous thromboembolism	European	IVW	3	0.117	1.124 (1.019, 1.240)	0.019
			MR-Egger	3	-0.044	0.957 (0.488, 1.885)	0.920
			Weighted median	3	0.104	1.110 (0.998, 1.233)	0.043
			Sample mode	3	0.107	1.107 (0.971, 1.263)	0.268
			Weighted mode	3	0.103	1.103 (0.980, 1.254)	0.243
Hypothyroidism	Venous thromboembolism	European	IVW	79	0.470	1.601 (0.693, 3.699)	0.270
			MR-Egger	79	-0.361	0.697 (0.111, 4.386)	0.939
			Weighted median	79	0.001	0.999 (0.275, 3.634)	0.900
			Sample mode	79	0.228	1.256 (0.073, 2.588)	0.228
			Weighted mode	79	-0.558	0.572 (0.084, 3.899)	0.570

Abbreviations: FT4: free thyroxine; TSH: thyrotropin; IVW: inverse variance weighted; nSNP: number of single nucleotide polymorphisms; OR: odds ratio; CI: confidence interval.