Research Article
Effects of Hyperthyroidism on Venous Thromboembolism: A Mendelian Randomization Study
Table 6
Mendelian randomization analysis for estimating the associations between thyroid function and dysfunction and venous thromboembolism risk.
| Exposure | Outcome | Ancestry | MR | Methods | nSNP | Beta | OR (95% CI) | value |
| FT4 | Venous thromboembolism | European | IVW | 15 | -0.009 | 0.991 (0.825, 1.190) | 0.919 | MR-Egger | 15 | 0.038 | 1.039 (0.667, 1.619) | 0.869 | Weighted median | 15 | 0.024 | 1.024 (0.858, 1.224) | 0.789 | Sample mode | 15 | -0.024 | 0.976 (0.716, 1.330) | 0.880 | Weighted mode | 15 | 0.071 | 1.074 (0.886, 1.302) | 0.481 | TSH | Venous thromboembolism | European | IVW | 36 | 0.019 | 1.019 (0.931, 1.115) | 0.684 | MR-Egger | 36 | -0.032 | 0.968 (0.771, 1.216) | 0.782 | Weighted median | 36 | 0.011 | 1.011 (0.880, 1.161) | 0.880 | Sample mode | 36 | -0.014 | 0.987 (0.792, 1.230) | 0.950 | Weighted mode | 36 | 0.009 | 1.009 (0.867, 1.175) | 0.907 | Hyperthyroidism | Venous thromboembolism | European | IVW | 3 | 0.117 | 1.124 (1.019, 1.240) | 0.019 | MR-Egger | 3 | -0.044 | 0.957 (0.488, 1.885) | 0.920 | Weighted median | 3 | 0.104 | 1.110 (0.998, 1.233) | 0.043 | Sample mode | 3 | 0.107 | 1.107 (0.971, 1.263) | 0.268 | Weighted mode | 3 | 0.103 | 1.103 (0.980, 1.254) | 0.243 | Hypothyroidism | Venous thromboembolism | European | IVW | 79 | 0.470 | 1.601 (0.693, 3.699) | 0.270 | MR-Egger | 79 | -0.361 | 0.697 (0.111, 4.386) | 0.939 | Weighted median | 79 | 0.001 | 0.999 (0.275, 3.634) | 0.900 | Sample mode | 79 | 0.228 | 1.256 (0.073, 2.588) | 0.228 | Weighted mode | 79 | -0.558 | 0.572 (0.084, 3.899) | 0.570 |
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Abbreviations: FT4: free thyroxine; TSH: thyrotropin; IVW: inverse variance weighted; nSNP: number of single nucleotide polymorphisms; OR: odds ratio; CI: confidence interval.
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