|
| Reference | Country | participants | Participants’ age group | Setting | Sampling method | Performed tests | Drug participants reported to be allergic |
|
| Studies conducted in children population |
| Caubet et al. [17] | Switzerland | 30 | Children | Patients (not specified) | Convenience sample | LTT, BAT | Beta-lactams |
| Chopra et al. [18] | Canada | 11 | Children | Patients (not specified) | Retrospective | LTT | Amoxicillin |
| Tsuge et al. [19] | Japan | 18 | Children | Patients (not specified) | Convenience sample | CD4+ cell proliferation, IFN-γ secretion | Phenytoin |
| Haw et al. [40] | United Kingdom | 16 | Children and adults | Patients (not specified) | Retrospective | Lymphocyte proliferation assay (LPA), combination of cytokine assays | n/a |
|
| Studies conducted in children and adult population |
| Ban et al. [20] | Korea | 12 | Children and adults | Inpatients and outpatients | Convenience sample | LTT | First-line antituberculosis medication (isoniazid, ethambutol, rifampin, and pyrazinamide) |
| Fu et al. [21] | China | 6 | Children and adults | Patients (not specified) | Convenience sample | LTT | Carbamazepine, acetaminophen, amoxicillin, penicillin, and cephazolin |
| Karami et al. [22] | Iran | 48 | Children and adults | Patients (not specified) | Consecutive sample | LTT | Anticonvulsant (phenobarbital, phenytoin, carbamazepine, and lamotrigine) |
| Orasch et al. [23] | Switzerland | 20 | Children and adults | Patients (not specified) | Convenience sample | LTT | Local anaesthetics |
| Polak et al. [24] | United Kingdom | 57 | Children and adults | Patients (not specified) | Convenience sample | ELISpot (IFN-γ, IL-4), LTT | Multiple drugs |
| Sachs et al. [29] | Germany | 20 | Children and adults | Patients (not specified) | Consecutive sample | ELISA (IL-5, IL-10, and IFN-γ), LTT | Multiple drugs |
|
| Studies conducted in adult population |
| Abuaf et al. [30] | France | 20 | Adults | Patients (not specified) | Convenience sample | BAT | Amoxicillin |
| Ben-Said et al. [31] | France | 56 | Adults | Patients (not specified) | Convenience sample | IFN-γ ELISpot | Beta-lactams |
| Halevy and Grossman [32] | Israel | 12 | Adults | Patients (not specified) | Convenience sample | IFN-γ release test | Multiple drugs |
| Harenberg et al. [33] | Germany | 9 | Adults | Patients (not specified) | Convenience sample | Intracutaneous tests, HIPA assay, and heparin-induced IgG assay | LMW heparin |
| Hari et al. [34] | Switzerland | 22 | Adults | Inpatients and outpatients | Convenience sample | LTT | Multiple drugs |
| Kalish et al. [35] | USA | 17 | Adults | Patients (not specified) | Convenience sample | LTT | Trimethoprim-sulfamethoxazole, sulfapyridine, hydrochlorothiazide, and furosemide |
| Lopez et al. [36] | Spain | 16 | Adults | Patients (not specified) | Convenience sample | LTT | Heparins |
| Luque et al. [37] | Spain | 47 | Adults | Patients (not specified) | Convenience sample | RAST, LTT | Beta-lactams |
| Ónodi-Nagy et al. [38] | Hungary | 10 | Adults | Patients (not specified) | Convenience sample | LTT | Penicillins (amoxicillin, clavulanic acid, and cefixime) |
| Porebski and Czarnobilska [42] | Poland | 47 | Adults | Patients (not specified) | Convenience sample | ELISpot assay, cytometric analysis, LTT, ELISA | Antiepileptic drugs (carbamazepine, oxcarbazepine, lamotrigine, and phenytoin) |
| Porebski et al. [41] | Poland | 32 | Adults | Patients (not specified) | Convenience sample | Electrochemiluminescence assay (ECL), IFN-γ-ELISpot, LTT, IFN-γ-FACS, and IFN-γ-ELISA | Antiepileptic drugs (carbamazepine, oxcarbazepine, and lamotrigine) |
| Rodriguez-Pena et al. [43] | Spain | 17 | Adults | Patients (not specified) | Convenience sample | LTT | Amoxicillin |
| Romano [44] | Italy | 24 | Adults | Patients (not specified) | Convenience sample | RAST | Aminopenicillins |
| Schmid et al. [45] | Switzerland | 6 | Adults | Patients (not specified) | Convenience sample | LTT | Quinolones (ciprofloxacin, norfloxacin, moxifloxacin) |
| Schnyder and Pichler [46] | Switzerland | 12 | Adults | Patients (not specified) | Convenience sample | CAP, LTT | Amoxicillin and penicillin G |
| Srinoulprasert and Pichler [48] | Switzerland | 6 | Adults | Patients (not specified) | Convenience sample | Modified LTT, LTT | Amoxicillin, sulfamethoxazole, clavulanic acid, trimethoprim, and iomeron |
| Tanvarasethee et al. [49] | Bangkok | 25 | Adults | Patients (not specified) | Convenience sample | ELISpot | Ceftriaxone, ceftazidime |
| Trautmann et al. [47] | Germany | 37 | Adults | Patients (not specified) | Convenience sample | Modified LTT, LTT | Beta-lactams |
| Whitaker et al. [39] | United Kingdom | 39 | Adults | Patients (not specified) | Convenience sample | LTT | Piperacillin |
|
| Studies conducted in unknown population |
| Nyfeler and Pichler [25] | Switzerland | 102 | n/a | Patients (not specified) | Retrospective | LTT | Multiple drugs |
| Rozieres et al. [26] | France | 38 | n/a | Patients (not specified) | Convenience sample | IFN-γ ELISpot, LTT | Amoxicillin, ticarcillin |
| Sachs et al. [27] | Germany | 11 | n/a | Patients (not specified) | Convenience sample | LTT | Aminopenicillins |
| Warrington and Tse [28] | Canada | 12 | n/a | Patients (not specified) | Convenience sample | LTT | Penicillin |
|
