Research Article
Copy Number Variation and Frequency of rs179008 in TLR7 Gene Associated with Systemic Lupus Erythematosus in Two Mexican Populations
Table 2
Association analysis of the allelic and genotypic frequencies of rs179008 (A>T) in SLE patients and healthy controls from Yucatán and Central Mexico.
| Location | Allele and genotype | SLE patients | HW | Healthy controls | HW | OR | 95% IC | |
| Yucatán | A | 168 (84%) | | 154 (75%) | | Reference | 0.58 | 0.3577-0.9620 | 3.4 -02 | T | 32 (16%) | | 50 (25%) | | A/A | 69 (69%) | 0.45 | 58 (57%) | 1 | Reference | A/T | 30 (30%) | | 38 (37%) | | 0.66 | 0.3669-1.200 | 1.7 -01 | T/T | 1 (1%) | | 6 (6%) | | 0.14 | 0.0163-1.1974 | 7.3 -02 | Central Mexico | A | 152 (50%) | | 148 (61%) | | Reference | 1.55 | 1.1025-2.1896 | 1.2 -02 | T | 150 (50%) | | 94 (39%) | | A/A | 5 (3%) | < 0.0001 | 30 (25%) | < 0.0001 | Reference | A/T | 140 (93%) | | 88 (73%) | | 9.54 | 3.5696-25.5252 | < 1.0 -04 | T/T | 6 (4%) | | 3 (2%) | | 12 | 2.2400-64.2865 | 3.7 -03 |
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