Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma

Table 5

Univariate and multivariate Cox analysis of esophageal carcinoma specific survival.

Variables	Univariate		Multivariate^a
	HR (95% CI)	^b	HR (95% CI)	^b
SCARA5		0.35		0.96
Lower	1		1
Higher	0.79 (0.49-1.28)		0.98 (0.56-1.74)
Sex		0.03		0.05
Female	1		1
Male	1.85 (1.07-3.20)		1.94 (0.99-3.82)
Age (y)		0.84		—
≥60	1		—
<60	1.05 (0.68-1.63)		—
Clinical stage		<0.01		—
I-II	1		—
III	2.43 (1.54-3.86)		—
Tumor location		0.35		—
Lower	1		—
Middle	0.78 (0.42-1.45)		—
Upper	0.37 (0.09-1.57)		—
T classification		0.02		<0.01
T1-T2	1		1
T3-T4	2.24 (1.15-4.37)		2.91 (1.30-6.51)
N classification		0.01		0.11
N0	1		1
N1-3	1.80 (1.15-2.82)		1.55 (0.90-2.68)
Differentiation		0.65		—
Well	1		—
Moderately	1.59 (0.58-4.41)		—
Poorly	1.45 (0.50-4.20)		—
Tumor volume (cm^3)		<0.01		<0.01
≤22.5	1		1
>22.5	2.22 (1.36-3.64)		2.30 (1.39-3.80)
Number of tumors		0.59		—
1	1		—
2	1.33 (0.48-3.65)		—
Longest diameter of tumor (cm)		<0.05		—
<5	1		—
≥5	1.63(1.00-2.63)		—

Abbreviations: T: tumor; N: lymph node; clinical stage: according to the American Joint Committee on Cancer staging standard; tumor volume: . ^aAdjusted by Cox proportional hazard regression model including all factors, as categorized in Table 4. ^bBold type indicates statistical significance.