The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia

Figure 1

LNT inhibited LPS-induced activation of BV2 cells. The proliferation rate (percentage of control) of BV2 cells was measured by CCK-8 assay. (a) BV2 cells were treated with LNT (400 μg/ml), LPS (1 μg/ml), and LNT (400 μg/ml) with LPS (400 μg/ml) for 24 h. (b) The graph represents the quantification of activated BV2 cells. (c) The protein levels of Iba1 were detected by Western blotting. (d) Typical morphological features of cells were detected by microscopy. (e) Representative immunostaining showing the distribution of Iba1 in the experimental groups. Black or white arrows indicate representative cells in the treatment group. All data are presented as the . (d); (e). Statistical analysis was performed using one-way ANOVA followed by the post hoc Tukey tests. (, , and .)

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