The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia

<div>LNT ameliorated CPZ-induced motor dysfunction and demyelination in the CPZ model. (a) Scheme of the experimental protocol of LNT treatment. (b) Effects of LNT on the body weight in CPZ model. (c) Rotarod test. The latency time of each group to stay on the rotarod was recorded. (d) A histogram of quantitative data of the LFB-positive area in the corpus callosum. (e) A histogram of quantitative data of MBP immunostaining in the corpus callosum. (f) Representative images of LFB staining in the corpus callosum. (g) Immunostaining of MBP in the corpus callosum. 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Statistical analysis was performed using one-way ANOVA followed by the post hoc Tukey tests. 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Journal of Immunology Research

fig4

Figure 4

Figure 4: The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia 

Figure 4 | The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia 