The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia

Figure 5

LNT promoted myelin regeneration by regulating the dectin-1 receptor. (a) Scheme of the experimental protocol of LNT and Lam treatment. (b) Rotarod test. The latency time of each group to stay on the rotarod was recorded. (c) Immunostaining of dectin-1 in the corpus callosum. (d) The protein level of dectin-1 was detected by Western blot. (e) Histogram of quantitative data of dectin-1-positive cells. (f) A histogram of quantitative data of MBP immunofluorescence staining in the corpus callosum. (g) A histogram of quantitative data of the LFB-positive area in the corpus callosum. (h) Representative photographs of LFB staining in the corpus callosum. (i) Immunostaining of MBP in the corpus callosum. White arrows indicate representative cells in the treatment group. All data are presented as the . (c); (h, i). Statistical analysis was performed using one-way ANOVA followed by the post hoc Tukey tests. (, , and .)

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