Deoxyschizandrin Inhibits the Proliferation, Migration, and Invasion of Bladder Cancer Cells through ALOX5 Regulating PI3K-AKT Signaling Pathway

Figure 2

Deoxyschizandrin inhibits the migration, invasion, and in vitro tumorigenesis of bladder cancer cell lines. (a and b) Wound healing showed that Deoxyschizandrin significantly suppressed migration in HT1376 cells. (c and d) Wound healing showed that Deoxyschizandrin significantly suppressed migration in J82 cells. (e and f) Transwell assays showed that Deoxyschizandrin significantly suppressed invasion in HT1376 cells. (g and h) Transwell assays showed that Deoxyschizandrin significantly suppressed invasion in J82 cells. (i and j) The expression of E-cadherin, Vimentin protein level with Deoxyschizandrin treatment in HT1376 and J82 cells. (k and l) BALB/c nude mice injected into HT1376 and J82 cells had smaller volume tumor xenografts with Deoxyschizandrin treat. Data represent . compared with negative control.

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