Echinacoside Induces Mitochondria-Mediated Pyroptosis through Raf/MEK/ERK Signaling in Non-Small Cell Lung Cancer Cells

<div>Ech restrained the activity of A549 and H1299 cells. (a) Molecular framework of Ech. (b, c) Cell viabilities of A549 and H1299 cells measured by the CCK-8 method under Ech treatments were used to calculate the IC<sub>50</sub> values. (d) The proliferation suppression impact of Ech in A549 and H1299 cells was further verified by EdU assay and relative EdU-positive ratio, respectively. <span class="nowrap"><svg height="11.9544pt" id="M6" style="vertical-align:-3.42942pt" version="1.1" viewbox="-0.0498162 -8.52498 65.8961 11.9544" width="65.8961pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M372 352C427 368 507 407 507 502C507 548 486 592 451 616C420 638 376 650 301 650H44V622C124 616 128 610 128 527V123C128 40 122 34 36 28V0H257C336 0 402 12 453 40C512 72 548 124 548 191C548 291 471 335 372 350V352ZM213 362V558C213 591 216 602 226 608C235 614 258 618 282 618C377 618 415 558 415 490C415 406 369 362 260 362H213ZM213 328H258C380 328 450 283 450 181C450 76 377 35 296 34C231 34 213 53 213 125V328Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.761,0)"><path d="M433 39L423 65C413 59 399 54 387 54C370 54 352 69 352 114V299C352 352 342 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Journal of Immunology Research

fig1

Figure 1

Figure 1: Echinacoside Induces Mitochondria-Mediated Pyroptosis through Raf/MEK/ERK Signaling in Non-Small Cell Lung Cancer Cells 