Sonic Hedgehog Promotes Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Rho/ROCK Signaling

<div>Smo agonist and antagonist regulate the expression of Rho/ROCK-related proteins. (a) The expression of p-MTPT1, MTPT, RhoA, and Smo was detected by western blot. (b) The relative expression of Smo was upregulated in the treatment of purmorphamine, and it was downregulated by using cyclopamine. (c) The phosphorylation level of MYPT-1The was upregulated in the treatment of purmorphamine, and it was downregulated after adding cyclopamine. 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Journal of Immunology Research

fig3

Figure 3

Figure 3: Sonic Hedgehog Promotes Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Rho/ROCK Signaling 