Research Article
Sonic Hedgehog Promotes Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Rho/ROCK Signaling
Figure 4
Shh signaling promotes the proliferation of RA-FLS via the Rho/ROCK pathway. (a) RA-FLS were treated with purmorphamine, purmorphamine combined with Y27632, Y27632, or cyclopamine for 48 h. The cell proliferation rate was measured with a CCK8 assay. (b, c) RA-FLS were treated with purmorphamine, purmorphamine combined with Y27632, or cyclopamine for 48 h, and the proportion of cells in the S phase was detected by flow cytometry. , .
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