Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients

Figure 2

GZMB and NRP1 transcripts in Tregs of GV patients and controls. GZMB and NRP1 transcripts in Tregs of 52 GV patients and 48 controls were analyzed by Nonparametric Mann–Whitney U test. (a) GZMB transcripts in GV, SV, and AV vs controls’ Tregs (, , and , respectively). GZMB transcripts in AV vs SV Tregs (). GZMB transcripts in GV, SV, and AV Tregs before and after calcium treatment (, , and ). (b) GZMB transcripts in 50-75% severe GV vs 10-25% mild GV Tregs (). GZMB transcripts in moderate GV (25-50% VASI) vs mild GV (10-25% VASI) and severe GV (50-75% VASI) Tregs ( and , respectively). GZMB transcripts in mild GV, moderate GV, and severe GV Tregs before and after calcium treatment (, , and ). (c) There was a 0.44-, 0.58-, and 0.30-fold changes in GZMB transcripts for GV, SV, and AV Tregs as compared to controls. (d) NRP1 transcripts in GV, SV, and AV vs controls’ Tregs (, , and , respectively). NRP1 transcripts in AV vs SV Tregs (). NRP1 transcripts in GV, SV, and AV Tregs before and after calcium treatment (, , and ). (e) NRP1 transcripts in severe GV (50-75% VASI) vs mild GV (10-25% VASI) Tregs (). NRP1 transcripts in moderate GV (25-50% VASI) vs mild GV (10-25% VASI) and severe GV (50-75% VASI) Tregs ( and , respectively). NRP1 transcripts in mild GV, moderate GV, and severe GV Tregs before and after calcium treatment (, , and ). (f) There was a 0.45-, 0.58-, and 0.40-fold changes in NRP1 transcripts for GV, SV, and AV Tregs when compared to controls.

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