Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients

Figure 3

SERPINB9 and ITPR1 transcripts in Tregs of GV patients and controls. SERPINB9 and ITPR1 transcripts in Tregs of 52 GV patients and 48 controls were analyzed by nonparametric Mann–Whitney U test. (a) SERPINB9 transcripts in GV, SV, and AV vs controls’ Tregs (, , and , respectively). SERPINB9 transcripts in AV vs SV Tregs (). SERPINB9 transcripts in GV, SV, and AV Tregs before and after calcium treatment (, , and ). (b) SERPINB9 transcripts in severe GV (50-75% VASI) vs mild GV (10-25% VASI) Tregs (). SERPINB9 transcripts in moderate GV (25-50% VASI) vs mild GV (10-25% VASI) and severe GV (50-75% VASI) Tregs ( and , respectively). SERPINB9 transcripts in mild GV, moderate GV, and severe GV Tregs before and after calcium treatment (, , and , respectively). (c) There was a 0.32-, 0.54-, and 0.25-fold changes in SERPINB9 transcripts for GV, SV, and AV Tregs when compared to controls. (d) ITPR1 transcripts in GV, SV, and AV vs controls’ Tregs (, , and , respectively). ITPR1 transcripts in AV vs SV Tregs (). ITPR1 transcripts in GV, SV, and AV Tregs before and after calcium treatment (, , and ). (e) ITPR1 transcripts in severe GV (50-75% VASI) vs mild GV (10-25% VASI) Tregs (). ITPR1 transcripts in moderate GV (25-50% VASI) vs mild GV (10-25% VASI) and severe GV (50-75% VASI) Tregs ( and , respectively). ITPR1 transcripts in mild GV, moderate GV, and severe GV Tregs before and after calcium treatment (, , and ). (f) There was a 0.54-, 0.62-, and 0.28-fold changes in ITPR1 transcripts for GV, SV, and AV Tregs when compared to controls.

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