Decreased Jumonji Domain-Containing 3 at the Promoter Downregulates Hematopoietic Progenitor Kinase 1 Expression and Cytoactivity of T Follicular Helper Cells from Systemic Lupus Erythematosus Patients

<div>JMJD3, EZH2, and UTX bindings at the HPK1 promoter in healthy and SLE Tfh cells. (a–c) Relative levels of JMJD3 (a), EZH2 (b), and UTX (c) binding within the HPK1 promoter region in healthy and SLE Tfh cells were analyzed by combining ChIP and qPCR assays. Results were normalized to input DNA (total chromatin). (d–f) The correlations between H3K27me3 enrichment (d), HPK1 mRNA level (e), protein level (f), and JMJD3 binding in SLE Tfh cells.</div>

Journal of Immunology Research

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Figure 2: Decreased Jumonji Domain-Containing 3 at the Promoter Downregulates Hematopoietic Progenitor Kinase 1 Expression and Cytoactivity of T Follicular Helper Cells from Systemic Lupus Erythematosus Patients 

Figure 2 | Decreased Jumonji Domain-Containing 3 at the Promoter Downregulates Hematopoietic Progenitor Kinase 1 Expression and Cytoactivity of T Follicular Helper Cells from Systemic Lupus Erythematosus Patients 