Decreased Jumonji Domain-Containing 3 at the Promoter Downregulates Hematopoietic Progenitor Kinase 1 Expression and Cytoactivity of T Follicular Helper Cells from Systemic Lupus Erythematosus Patients

Figure 5

H3K4me3 and MLL1 enrichments at the HPK1 promoter in healthy and SLE Tfh cells. (a, b) Relative H3K4me3 (a) and MLL1 (b) enrichments at the HPK1 promoter in healthy and SLE Tfh cells were measured by combining ChIP and qPCR assays. Results were normalized to input DNA (total chromatin). (c, d) The correlations between H3K4me3 enrichment (c), MLL1 enrichment (d), and JMJD3 binding in SLE Tfh cells.

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