IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING

Figure 1

IL6 mediated excessive ROS production in EC cells. (a) The NOX activity in EC cells in the presence of IL6 treatment (2, 4, 8, 16, and 32 ng/ml) for 4, 8, 12, 16, 20, and 24 hr. The NOX activity was measured and expressed as folds changes to that of untreated control cells (designated as 1). (b) The cellular ROS content in EC cells in the presence of IL6 treatment (2, 4, 8, 16, and 32 ng/ml) for 4, 8, 12, 16, 20, and 24 hr. The cellular ROS was measured and expressed as folds changes to that of untreated control cells (designated as 1). (c) Immunofluorescence staining of mitochondrial superoxide production from IL6-treated EC cells. H₂O₂ was considered a positive control. The data were represented as the ; or .

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