IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING

<div>IL6 affects mitochondrial damage and mtDNA leakage. (a) Western blot of whole-cell extracts (WCE), pellets (Pel), cytosolic extracts (Cyt), and mitochondrion (Mito). (b) qRT-PCR analysis of cytosolic DNA (mtDNA) treated with NC, IL6, or IL6 and NAC, respectively. (c) qRT-PCR analysis of cytosolic DNA (nuclear DNA) treated with NC, IL6, or IL6 and NAC, respectively. (d) Immunofluorescence staining of mtDNA (red), and dsDNA (green) treated with NC, IL6, or IL6 and NAC, respectively. 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Journal of Immunology Research

fig2

Figure 2

Figure 2: IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING 