Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling

Figure 5

Effect of TLR7 and TLR8 antagonists on H. pylori infection-mediated inflammatory cytokine expression in THP-1 cells. THP-1 cells were uninfected (mock), infected with H. pylori J99 strain at MOI 10 for 16 hours (J99), or infected and treated with TLR7 inhibitor (ODN20958 + J99) or TLR7/8 inhibitor (ODN20959 + J99) for 4 hours prior to infection. Data is presented as from one experiment run in triplicate and is representative of two independent experiments. Statistical significance was analyzed using Student’s -test (; ; ; ns: not significant).

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