Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling

Figure 7

Unperturbed bacteria internalization in THP-1 macrophage with or without TLR7 and TLR8 inhibition. THP-1 cells were uninfected (mock), infected with H. pylori J99 strain conjugated with FITC at MOI 10 for 16 hours, or infected after treatment with TLR7 inhibitor (ODN20958 + J99) or TLR7/8 inhibitor (ODN20959 + J99) for 4 hours. Cells were stripped off extracellular bacteria and viewed under fluorescent microscope. Data are representative of at least 10 images captured.