Comparison of Transcriptomic Signatures between Monkeypox-Infected Monkey and Human Cell Lines

Figure 2

Analytical results of Gene Ontology (GO) enrichment accompanied by heatmap visualization in two separate monkeypox-infected models. (a) Comparison of gene expression patterns between the monkeypox-infected Macaca mulatta kidney epithelial (MK2) cells and the mock control. Cluster 1 (c1) contained the most significant highly expressed genes and pathways in the monkeypox-infected group, whereas c2 exerted an opposite trend. The GO analysis suggested that inflammatory and chemokine-related peptidoglycan pathways were significantly correlated with the monkeypox-infected Macaca mulatta kidney epithelial (MK2) cell model. (b) Comparison of gene expression patterns between the monkeypox-infected human immortal epithelial cancer (HeLa) cell model and the mock control. Cluster 1 (c1) contained the most significantly highly expressed genes and pathways in the monkeypox-infected group, whereas c2 exerted an opposite trend. The GO analysis suggested that nucleosome assembly and cytoskeleton-related pathways were found to be significantly correlated with the human immortal epithelial cancer (HeLa) cell model.

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