Comparison of Transcriptomic Signatures between Monkeypox-Infected Monkey and Human Cell Lines

Figure 3

Overexpressed pathways shared by the two in vitro monkeypox-infected models. (a) The top 5% of overexpressed genes shared by the GSE21001 and GSE36854 datasets, filtered by a Venn diagram, represent the monkeypox-infected Macaca mulatta kidney epithelial (MK2) cell model and the human immortal epithelial cancer (HeLa) cell model. (b) The most enriched biological pathways corresponding to genes from the shortlist of upregulated genes shared by the two models, in order of decreasing log ( values). (c) The most enriched metabolic pathways as components of the Endogenous Metabolic Networks corresponding to genes from the shortlist of upregulated genes shared by the two models, in order of decreasing log ( values). (d) Related pathways and network analyses by MetaCore confirmed the vital role of the “immune response_IL-1 signaling” pathway in both monkeypox-infected models. (e) Endogenous Metabolic Networks analyses by MetaCore confirmed the vital role of the “N-acyl-sphingosine phosphate pathway” in both monkeypox-infected models.

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