Comparison of Transcriptomic Signatures between Monkeypox-Infected Monkey and Human Cell Lines

Figure 4

Overview of protein-protein-interacting networks inferred from overexpressed genes in the monkeypox-infected Macaca mulatta kidney epithelial (MK2) cell model and the human immortal epithelial cancer (HeLa) cell model. (a) Similar transcriptome patterns obtained from the GSE21001 and GSE36854 datasets were filtered by a Venn diagram. Shortlist of the top 1% of upregulated genes shared by the two monkeypox-infected models. (b) Distribution of 24 coregulated genes inferred from the above shortlist, presented using box plot visualizations. (c) STRING analyses revealed the protein-protein-interacting network of the 24 co-regulated genes, separated by clusters in different colors. Colored nodes represent 24 target genes as input, while gray nodes represent the corresponding proteins.

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