Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib

<div>Relationship between the MUS81 expression and the sensitivity to Olaparib. (a) CRPC cell viability after 80 <i>μ</i>M Olaparib treatment. (b) Cell viability of PC3, PC3-LV, PC3-sh, DU145, DU145-LV, and DU145-sh cells at <svg height="13.7421pt" id="M32" style="vertical-align:-2.1507pt" version="1.1" viewbox="-0.0498162 -11.5914 88.2844 13.7421" width="88.2844pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M285 378C315 398 338 416 353 432C373 451 384 474 384 503C384 579 325 635 236 635H235C182 635 136 610 108 579L65 516L85 496C110 533 150 575 205 575C258 575 300 543 300 481C300 407 232 369 141 339L147 310C163 315 188 321 211 321C268 321 338 284 338 192C338 94 288 40 217 40C160 40 119 68 93 91C85 98 77 97 69 91C60 84 47 71 46 58C44 46 48 35 62 22C75 10 116 -12 162 -12C234 -12 424 62 424 224C424 297 373 359 285 376V378Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.146,0)"><path d="M528 54L331 254L528 455L492 493L294 291L96 493L60 455L257 254L60 54L96 16L294 217L492 16L528 54Z"></path></g><g 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Journal of Immunology Research

fig5

Figure 5

Figure 5: Expression of MUS81 Mediates the Sensitivity of Castration-Resistant Prostate Cancer to Olaparib 