A Novel Identified Long Intergenic Noncoding RNA, LINC01574, Contributes to Breast Cancer Deterioration via the Regulation of miR-6745/TTYH3 Axis

<div>LINC01574 affected TTYH3 expression by regulation of miR-6745. (a) miRWalk, TargetScan7, and miRDB algorithm were used to predicted downstream target mRNAs with potential binding sites for miR-6745. (b) TCGA and CPTAC databases were used to analyze the expression of TTYH3 and survival in BC patients. (c) QRT-PCR quantitatively detected the transcriptional expression of TTYH3 in BC tumor tissues. (d) After corresponding transfection, the mRNA level of miR-6745 and TTYH3 and the protein level of TTYH3 were analyzed. (e) The interaction between miR-6745 and TTYH3 was verified through luciferase reporter assay. 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Journal of Immunology Research

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Figure 5

Figure 5: A Novel Identified Long Intergenic Noncoding RNA, LINC01574, Contributes to Breast Cancer Deterioration via the Regulation of miR-6745/TTYH3 Axis 

Figure 5 | A Novel Identified Long Intergenic Noncoding RNA, LINC01574, Contributes to Breast Cancer Deterioration via the Regulation of miR-6745/TTYH3 Axis 