Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis
Table 4
Circulating cytokine and chemokine levels in chronic hepatitis B patients with different clinical characteristics.
Groups
N
Age
Male
IL-1β
IL-6
IL-17
IL-10
IL-8
IP-10
MCP-1
MIP-1β
HBeAg statuses
Negativity
25 (30.86%)
20 (80.00%)
3.28 (2.01–5.30)
15.68 (13.10–25.71)
45.54 (41.42–52.38)
4.86 (4.26–11.43)
49.77 (22.01–234.39)
2730.17 (1987.72–5695.15)
46.18 (34.93–66.37)
238.39 (158.31–558.52)
Positivity
56 (69.14%)
33 (58.93%)
3.81 (2.37–5.57)
15.68 (13.01–29.68)
47.59 (40.38–54.43)
4.86 (3.90–7.32)
50.27 (25.20–161.79)
2341.39 (1330.84–3707.99)
52.21 (34.56–74.35)
218.35 (137.65–415.40)
value
0.267
0.065
0.484
0.744
0.416
0.681
0.959
0.065
0.419
0.533
HBV DNA load
Low
17 (20.99%)
16 (94.12%)
2.92 (2.08–4.46)
14.51 (12.93–23.22)
43.48 (38.66–53.41)
4.86 (4.38–6.83)
49.77 (26.36–228.16)
2227.33 (1608.40–3224.34)
46.58 (34.11–79.88)
202.52 (147.17–452.52)
High
64 (79.01%)
37 (57.81%)
3.84 (2.38–5.60)
15.68 (13.35–29.68)
47.59 (41.58–53.75)
4.86 (3.90–7.82)
50.27 (23.65–207.87)
2580.68 (1753.78–4306.71)
49.70 (34.72–68.11)
233.67 (139.44–480.21)
value
0.230
0.005
0.200
0.580
0.265
0.948
0.724
0.302
0.424
0.889
Liver function
Normal
35 (43.21%)
21 (60.00%)
3.75 (2.18–5.69)
16.01 (13.84–37.77)
47.59 (42.10–53.75)
4.50 (3.90–14.86)
52.98 (28.45–353.12)
1920.92 (1291.94–2880.56)
41.23 (34.41–67.16)
246.01 (169.28–375.22)
Abnormal
46 (56.79%)
32 (69.57%)
3.52 (2.32–5.27)
15.34 (12.68–25.70)
46.22 (39.01–53.75)
4.86 (4.32–6.95)
49.53 (22.01–172.64)
2941.38 (2154.07–4723.25)
56.36 (36.17–75.48)
200.30 (119.40–532.82)
value
0.949
0.370
0.886
0.258
0.554
0.896
0.230
0.006
0.098
0.321
Note: All cytokine and chemokine levels are reported as pg/mL. Data are expressed as frequency (percentage), , or median (interquartile), where appropriate. Quantitative data analysis was performed using Mann–Whitney test and Student’s -test. The test was used to analyze the categorical data.
