Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses

Figure 3

Arthritis severity in collagen-induced arthritis (CIA) is unaltered in the absence of PAD2. Six weeks after the first injection to induce CIA, (a) clinical scores and (b) paw thickness were assessed weekly ( mice, 6 experiments). Controls (), which received no injections and were cohoused with experimental mice, were also evaluated. At 17 weeks after the first injection, the front paws were fixed, embedded, sectioned, and stained with hematoxylin and eosin. (c) Representative images at 100x. Bar indicates 200 microns. (d) The extent of pannus development, cartilage destruction, and ankylosis were scored in a blinded manner ( mice, 6 experiments). All graphs depict . PAD2^+/+ versus PAD2^-/- data were compared by paired test, and no comparisons were significant.

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