HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop

Figure 1

HIF-1α and HIF-3α promote miR-630 expression under hypoxia. (a) Bar plot showed the increased RNA level of HIF1A and HIF3A under hypoxia by RT-qPCR experiment. (b) Western blot result showed the increased protein level of HIF1A and HIF3A under hypoxia. (c) Bar plot showed the DEmiR number in HIF-1α vs. in the vacant group and in HIF-3α vs. in the vacant group. (d) Hierarchical clustering heat map showed the elevated expression level of selected miRNAs in HIF-1α and HIF-3α OE samples. (e) Bar plot showed the increased expression level of miR-630 under hypoxia by RT-qPCR experiment. (f) Bar plot showed the expression level of miR-630 under hypoxia by RT-qPCR experiment.

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