Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19

Figure 1

Role of Tregs in COVID-19 patients: An increase in level of Tregs could play a negative role in COVID-19 patients by inhibiting antiviral T cell responses, resulting in the progression of COVID-19 disease (a). A decrease in level of Tregs could result in cytokine storm or recovery depending on the response of proinflammatory cytokines. Firstly, early increase in IL-2 could be associated with faster viral clearance and early immune response in asymptomatic COVID-19 patients. Secondly, the significant increase in T helper cells such as Th17 could be related to hyperinflammation and progression of COVID-19 disease (b).

(a)

(b)