Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19

Figure 2

Pathogenic and protective roles of MDSCs in COVID-19 patients: Severe COVID-19 patients had higher levels of MDSCs. This might result in an undesirable suppression of SARS-CoV-2-specific T cell responses, which can contribute to worse outcomes in these patients (a). MDSC expansion may help to limit an overly aggressive and possibly damaging immune responses by decreasing inflammation caused by hyperactivated T cells (b).

(a)

(b)