Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis

<div>The expression of chemokines was positively correlated with DIO-induced liver metastasis of PDAC in mice. (a) Volcano plot of different gene expression in ND liver and DIO liver. Each point represented gene mRNA levels, fold change for ND and DIO. 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(b, c) KEGG and GO pathway analysis on significantly upregulated genes between ND and DIO tissue samples. <span class="nowrap"><svg height="9.16198pt" id="M36" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.52498 61.2677 9.16198" width="61.2677pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M493 503C489 551 484 614 483 650H43V622C120 616 128 611 128 525V126C128 40 120 34 40 28V0H312V28C221 34 213 40 213 126V307H316C407 307 412 296 424 227H453V420H424C412 355 407 346 316 346H213V584C213 613 216 616 246 616H322C398 616 419 607 436 579C449 559 455 539 464 499L493 503Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.877,0)"><path d="M43 650V622C120 616 128 612 128 526V124C128 39 120 33 34 27V0H270C392 0 492 25 567 83C643 141 690 230 690 350C690 444 655 517 605 565C543 625 450 650 323 650H43ZM213 547C213 587 217 598 226 604C236 612 262 617 304 617C371 617 429 604 474 576C554 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The multiples of the expression of chemokines and chemokines receptors in DIO were marked on the graph.</div>

Journal of Immunology Research

fig3

Figure 3

Figure 3: Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis 