Genome-Wide Association and Transcriptome-Wide Association Studies Identify Novel Susceptibility Genes Contributing to Colorectal Cancer

Figure 2

Manhattan plots of the TWAS results. (a) Gene-level Manhattan plot of the TWAS results from the European colorectal cancer cohort. The -axis represents the genomic position (based on NCBI Build 37), and the -axis shows the -log₁₀ ( value). The red line represents the transcriptome-wide significance threshold (). (b) -scores of the TWAS results from the European colorectal cancer cohort. The -axis represents the genomic position (based on NCBI Build 37), and the -axis shows the -score from the association tests. The blue line indicates that -score is equal to 0. Red lines denote the Bonferroni-corrected significance threshold (, ). TWAS: transcriptome-wide association study.

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