Genome-Wide Association and Transcriptome-Wide Association Studies Identify Novel Susceptibility Genes Contributing to Colorectal Cancer

Table 1

List of the significant candidate genes identified by TWAS for colorectal cancer.

Genes	Tissues	Cytogenetic band	Best eQTLs	Best SNPs	-scores		PP4		PIPs	90% credible set
GREM1-AS1	Colon sigmoid	15q13.3	rs2611583	rs1919360	6.74		0.70	0.002	1	1
C11orf53	Colon transverse	11q23.1	rs6589218	rs7130173	-5.14		0.99	0.002	0.36	1
POU5F1B	Colon transverse	8q24.21	rs7014346	rs6983267	-5.05		0.73	0.003	1	1
DUSP10	Colon sigmoid	1q41	rs6695584	rs12125368	4.92		0.52	0.003	NA	NA
COLCA1	Colon transverse	11q23.1	rs6589220	rs7130173	-4.88		0.99	0.019	0.00477	0
COLCA2	Colon transverse	11q23.1	rs3087967	rs7130173	-4.87		0.99	0.001	0.48	1

FUSION, FOCUS, and colocalization were used to identify genes associated with CRC. And 1000 Genomes Phase 3 (Europe, ) data were used as the LD reference panel. is the value of TWAS result; TWAS: transcriptome-wide association study; PP4 shared eQTL and GWAS associations; was the result of each of the significant features using FUSION. PIP: posterior inclusion probability of fine-mapping; : 1 means included in the 90% credible set; 0 means not included in the 90% credible set of FOCUS. NA: not available.