ATXN2-Mediated PI3K/AKT Activation Confers Gastric Cancer Chemoresistance and Attenuates CD8⁺ T Cell Cytotoxicity

Figure 5

SP1 regulated the expression of ATXN2. (a) Transcription factors were identified using the JASPAR and PROMO databases. (b, c) The correlation between ATXN2 and SP1 and GATA3 and TCF4 in the TCIA database (b) and GEPIA database (c). (d) The expression of SP1 in the GEPIA database. (e) The correlation between SP1 and GC prognosis. (f, g) SP1 and ATXN2 expression in SGC7901 cells (f) and SGC7901/5-FU cells (g). (h, i) Dual luciferase reporter assay analysis of SP1 binding to the ATXN2 promoter. .

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